Heart schematic and relevant vessels.
ME 537 Fluid Mechanics of the
Cardiovascular System

Class time: Tu Th 2:30-3:50 MEB 102


Professor Alberto Aliseda
office: MEB 306
tel: 543-4910
email: aaliseda@u.washington.edu
office hours: after class or by appointment

Course description Lecture Notes
Reading_Assignments Syllabus Exams
Textbook Grading

Course Description

The material in this course will provide the student with the fundamental background in fluid mechanics and the necessary understanding of the anatomy and physiology of the human vascular system to carry out research in the area of cardiovascular fluid mechanics. Topics that will be covered include normal physiological flow in veins and arteries, flow related pathologies such as thrombosis, atherosclerosis, stenosis, aneurysms, heart valve dysfunction. Applications to mechanics-based medical devices and therapies will also be a significant part of the course.

Lecture Notes


Reading Assignments:

Heart Anatomy and Physiology: Chapter 1. Physical Principles Circulation

Circulation. Chapter 2. The Heart

Mechanical Properties Living Tissue. Chapter 3. Blood Rheology

Mechanical Properties Living Tissue. Chapter 5. Blood Flow Heart Lungs Arteries Veins

Circulation. Chapter 3. Sections 1-7. Flow in Arteries.

Circulation. Chapter 3. Sections 8-12. Wave Transmission in Arteries.

Midterm Exam. 

Final Exam. 


Primer on Cardiovascular Anatomy and Physiology.                                    Weeks 1&2
Introduction to Fluid and Solid Mechanics of the Vascular System:              Weeks 3&4
 Non-Linear Stress-Strain constitutive equations and Rheology.
Some classical problems in Cardiosvacular Fluid Mechanics: Poiseuille,       Weeks 5&6
Womersley, pulsatile flow in a tube with slowly varying cross section,
pulsatile flow in a curved vessel, pulsatile flow in a collapsible tube.

Flow in complex geometries: Flow separation, recirculation                         Weeks 7&8
and transition to turbulence          

Specific problems in Cardiovascular Mechanics:                                          Weeks 9&10
Flow in Heart Valves, Stenotic Arteries and Partially Occluded Veins.        


There is no single course textbook, but the material for the course has been developedmostly from the following books:

. Fung, Y. C. Biodynamics, Circulation . Springer-Verlag, New York, 1984.
2. Fung, Y. C., Biomechanics: Motion, Flow, Stress, & Growth . Springer-Verlag, New York, 1990.
3. Fung, Y. C., Biomechanics: Mechanical Properties of Living Tissue , 2 nd edition. Springer-Verlag, New York, 1993.
4. Caro, C. G., Pedley, T. J., Schroter, R. C., Seed, W. A. The Mechanics of the Circulation. Oxford Medical Publications, Oxford, 1978.


Homework               20%        
Personal Project       40%
Midterm                  15%
Final                       25%

University of Washington Emergency Procedures

Emergency procedures for building evacuation, earthquake, fire, hazardous materials,
    and other potential problems are at the following website:


<aaliseda@u.washington.edu> Thursday, April 20, 2017