Heart schematic and relevant vessels.
ME 599 Fluid Mechanics of the
Cardiovascular System

Class time: Mon Wed 11:30-12:50 MEB 242


Professor Alberto Aliseda
office: MEB 306
tel: 543-4910
email: aaliseda@u.washington.edu
office hours: MWF 9:00-9:50 or by appointment

Course description Lecture Notes
Syllabus Exams
Textbook Grading

Course Description

The material in this course will provide the student with the fundamental background in fluid mechanics and the necessary understanding of the anatomy and physiology of the human vascular system to carry out research in the area of cardiovascular fluid mechanics. Topics that will be covered include normal physiological flow in veins and arteries, flow related pathologies such as thrombosis, atherosclerosis, stenosis, aneurysms, heart valve disfunction. Applications to mechanics-based medical devices and therapies will also be a significant part of the course.

Lecture Notes

Assigned Homework Sets

Homework #1. Blood Rheology

Homework #2. Heart Valve Dynamics.

Homework #2. Paper:"Computational Evaluation of Platelet Activation Induced by a Bioprosthetic Heart Valve".

Midterm Exam. 

Final Exam. 


Primer on Cardiovascular Anatomy and Physiology.                                    Weeks 1&2
Introduction to Fluid and Solid Mechanics of the Vascular System:              Weeks 3&4
 Non-Linear Stress-Strain constitutive equations and Rheology.
Some classical problems in Cardiosvacular Fluid Mechanics: Poiseuille,       Weeks 5&6
Womersley, pulsatile flow in a tube with slowly varying cross section,
pulsatile flow in a curved vessel, pulsatile flow in a collapsible tube.

Flow in complex geometries: Flow separation, recirculation                         Weeks 7&8
and transition to turbulence          

Specific problems in Cardiovascular Mechanics:                                          Weeks 9&10
Flow in Heart Valves, Stenotic Arteries and Partially Occluded Veins.        


There is no single course textbook, but the material for the course has been developedmostly from the following books:

. Fung, Y. C. Biodynamics, Circulation . Springer-Verlag, New York, 1984.
2. Fung, Y. C., Biomechanics: Motion, Flow, Stress, & Growth . Springer-Verlag, New York, 1990.
3. Fung, Y. C., Biomechanics: Mechanical Properties of Living Tissue , 2 nd edition. Springer-Verlag, New York, 1993.
4. Caro, C. G., Pedley, T. J., Schroter, R. C., Seed, W. A. The Mechanics of the Circulation. Oxford Medical Publications, Oxford, 1978.


Homework               30%        
Personal Project       30%
Midterm                  15%
Final                       25%

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<aaliseda@u.washington.edu> Fri, Jan 18 2013